Experts share their favorite spots across the continent.
Set where the Peruvian Andes meet the Amazon Basin, its location is spectacular.
Walk through the ruins and discover stone terraces and temples amid mountains, peaks, and valleys.
Long exposure of Iguasu Falls.Credit:Gabriel_Amaral/Getty Images
Some speculate the site was built as a royal estate, but the true purpose remains unknown.
Stroll the city and see ancient Incan architecture mixed with baroque Spanish temples and monasteries.
Find achichastand and sip on the ancient Incan beverage or buy hand-woven fabrics and textiles to support local artisans.
A group of visitors in the ruins of Machu Picchu.Rory Fuller/Travel + Leisure
Life unfolds along the waterfront promenades, and street art is found everywhere, especially in the Barranco neighborhood.
Wildlife spotting is superb here, with guanacos, pumas, Andean condors, and Chilean flamingoes.
Rio is thoroughly intoxicatingcool, sexy, frivolous, and wildly atmospheric.
A woman viewing the Cusco cityscape in Peru.Chris Marinaccio/Travel + Leisure
It was the most dramatic setting of any city I know, says Hastings.
A visit during Carnival season ensures plenty of showy costumes, samba dancers, and dazzling parades.
Limited accommodations and a required park pass help keep this haven uncrowded.
A hiker on a trail in Sacred Valley.Lauren Breedlove/Travel + Leisure
Burgio suggests taking a speedboat tour along the coastline while you fish for your lunch.
Theres mountain biking, bungee jumping, waterfall hikes, and river rafting here, too.
It spans about 100 square miles, reaching heights of 255 feet.
People at a viewpoint in on Rainbow Mountain.Rory Fuller/Travel + Leisure
Brugio recommends visiting vineyards and wineries in the Lujan Valley and Uco Valley.
Delicious eats and beach clubs are found on shore.
A public plaza in Lima, Peru.Leopoldine Bauer/Travel + Leisure
A passenger in a row boat on Lake Titicaca.Leopoldine Bauer/Travel + Leisure
Landscape of Torres del Paine National Park.Rory Fuller/Travel + Leisure
Santiago Chile’s cityscape.Maria Ligaya/Travel + Leisure
The red mountains of the Atacama Desert.Rory Fuller/Travel + Leisure
The Rano Raraku Quarry on Easter Island.powerofforever/Getty Images
A vineyard in Maipo Valley.Edwin Remsberg/Getty Images
An SUV on the white salt flats of Uyuni.Chris VR/Travel + Leisure
A boat ride down the Amazon River.Rory Fuller/Travel + Leisure
View of Sugarloaf Mountain in Rio de Janeiro, Brazil.Nikada/Getty Images
Dos Porcos Bay in Fernando Do Noronha Marine National Park.Gonzalo Azumendi/Getty Images
Iguassu Falls from Argentina.Maria Ligaya/Travel + Leisure
A crocodile spotted in the Pantanal.Lauren Breedlove/Travel + Leisure
Colorful buildings in Cartagena, Colombia.ribeirorocha/Getty Images
Seals on a Galapagos Island beach.guenterguni/Getty Images
A major waterfall near Baños, Ecuador.Barbara Karminska/Getty Images
Plaza de San Francisco in Quito, Ecuador.Westend61/Getty Images
The large glacier known as Perito Moreno in Argentina.Leopoldine Bauer/Travel + Leisure
A vineyard in Mendoza, Argentina.Edsel Querini/Getty Images
The La Boca neighborhood in Buenos Aires, Argentina.Sharyn Umaña-Angers/Travel + Leisure
A lighthouse on Punta del Este, Uruguay.Maria Ligaya/Travel + Leisure
