As the mile markers decrease, Old Florida charm sharpens into focus.

So put the top down and cue Jimmy Buffet.

Here’s our guide to the best theFlorida Keyshas to offer.

Aerial view of a the highway that goes to the Florida Keys

Credit:Chris Marinaccio/Travel + Leisure

A stop intoAlabama Jack’sis a must, especially if you’re a first-timer.

Live music and the line of Harleys outside add to the honky-tonk scene.

Or rent kayaks and head out for a paddle through miles of mangrove-lined wilderness trails.

Palm trees lining a walkway to the water

Gina DeCaprio Vercesi

At theCoral Restoration Foundation, researchers are rearing and planting corals in undersea nurseries.

The resort partners with local environmental organizations to create eco-friendly guest programming.

At either spot, the famous Keys sunset is guaranteed to put on a memorable show.

Birds in emerald waters around a busy dock

Gina DeCaprio Vercesi

When it comes to relaxation, the resort offers a stunning adults-only enclave called Oasis Cay.

But before you do, take a ferry out to picturesque Pigeon Key for a dose of Keys history.

In the early 1900s, Florida tycoon Henry Flagler envisioned an Overseas Railroad linking mainland Florida to Key West.

View of bridge at sunset from the water

Gina DeCaprio Vercesi

Don’t forget to drop by Sandspur Beach, long considered one of the best in the Keys.

The Sunday afternoon barbecue is legendary.

Head out to explore the labyrinth of waterways around Stock Island on a guided kayak tour withLazy Dog Adventures.

People in kayaks navigating a mangrove forest

Gina DeCaprio Vercesi

It also has an eclectic mix oftop-rated hotelsto suit every traveler.

Find respite from the downtown bacchanalia at theParrot Key Hotel and Villas.

The entire property breathes Old Key West charm.

Boardwalk leading to an umbrella- and palm-adorned hotel

Gina DeCaprio Vercesi

Walkways edged with white-picket fences wind through tropical gardens past hidden swimming pools and quaint, two-story clapboard bungalows.

For a DIY adventure, a fleet of single-speed beach cruisers invites exploration.

At four miles long and two miles wide, Key West is made for biking.

Pedal through dappled sunlight along Whitehead Street to theErnest Hemingway Home and Museum.

Innovative cocktails, crisp white tablecloths, and dreamy island views round out a memorable evening.