The high-altitude route is one of the most spectacular and inhospitable on the planet.

Other than my guide, David Torres, I was the only human around to witness this extraordinary spectacle.

Nevertheless, I knew that the journey could be physically grueling.

Flamingos at a lagoon in Bolivia

A flamboyance of James’s flamingos on Bolivia’s Laguna Colorada.Credit:Nick Ballón

A faint smell of sulfur filled the air.

In some parts, the river had veins of brick-red bacteria snaking along its surface like licks of fire.

This one looks like a portal to the underworld, Torres said casually, stepping around a steamy cauldron.

View from a hotel guest room onto the Bolivian landscape

The view from a guest room at Explora’s Ramaditas Mountain Lodge, in Bolivia.Nick Ballón

Even in my half-awake state, I knew that I wasnt looking up.

I was seeing it reflected on the lake like sprinkled glitter.

At the bottom, streams of water cut through the salty white ground.

Pair of photos, one showing a luxury hotel with a volcano behind, and one showing a chef at work

From left: The Licancabur Volcano looms over Explora’s Atacama Lodge, near San Pedro de Atacama, Chile; a chef prepares breakfast in Chituca Mountain Lodge’s open kitchen.Nick Ballón

It would be a mass-extinction event that would end life in the Americas as we know it.

These nomadic tribes lived from 2,000 B.C.

Behind us, volcanic boulders the size of cars sheltered yaretas, chartreuse cushion plants that smelled like pinecones.

A guest lounge at a lodge in Bolivia

The lounge at Ramaditas Mountain Lodge, in Bolivia.Nick Ballón

The dark green building looked like part of the landscape, surrounded by rock and scrub.

The nearest big town was three hours away.

The isolation wasnt like what Id find in a jungle or on an island or amid dense forest.

Chairs and a table on a salt flat in Bolivia

A sunrise breakfast on the salt flat.Nick Ballón

I was up-in-the-clouds apart.

Not that it scared me; I was thrilled.All that space.

It felt like one of the greatest luxuries on earth.

Pair of photos, one showing a corner of a hotel with mountains in the distance, and one showing baskets of dried flowers

From left: The Chituca Mountain Lodge on Bolivia’s Altiplano, with its views of the Andes Mountains, is a stop on Explora’s travesí­a expedition; inside Bolivia’s Las Galaxias Grotto, once used for Indigenous burial ceremonies.Nick Ballón

Torres yelled, incredulous.

Our driver, Cruz, was surprised, too.

Theyre even harder to spot than the puma, Torres said, offering me his binoculars.

Two hikers descending a volcano

Descending the slope of Irruputuncu Volcano.Nick Ballón

But the cat had disappeared into distant shrubs by the time I could focus.

All I could see was its prey: viscachas, rodents easily mistaken for rabbits.

But I also knew these aches were worth the chance to see what lay ahead.

Pair of photos, one showing a hiker silhouetted against yellow soil and one showing a person in hot springs

From left: Hiking the Irruputuncu Volcano, in Chile, amid its yellow sulfur-rich gas; bathing in the Puritama Hot Springs at Atacama Lodge.Nick Ballón

As Torres had taught me, I moved slowly, breathed with intention, and drank water greedily.

Two hours later, we cautiously crested the lip of the active volcano.

A fury of pungent smoke spewed from competing vents.

Wide view of salt flats, with a vehicle and chairs shown small in the frame

Stopping for lunch on Bolivia’s Salar de Uyuni salt flat.Nick Ballón

At times, the air became so thick it seemed to block out the sun.

Turning back, we slid-jumped down Irruputuncus sandy slope as if we were descending a giant dune.

The color wasnt the bluish white of snow and ice, but rather a radiant, pink-hued ivory.

It rippled like the ocean and felt, as I walked across in my boots, like broken glass.

After a quick photo stop, we climbed back into the Land Cruiser and raced northward through the emptiness.

It felt liberating to accelerate after days of slow walking.

We hiked to the top.

For the first time in four days, we were no longer alone.

We watched as 4x4s containing other visitors appeared to crawl like tiny ants across the salar.

You completely lose perspective here, Torres explained of the illusion.

Its something thats always been present in our lives.

But who knows what will happen in the coming years?

We climbed up terraced fields of quinoa peppered with scarecrows.

I was feeling chipper, too, finally at ease with the elevation.

The color wasnt the bluish white of snow and ice, but rather a radiant, pink-hued ivory.

Our hot breaths were like cloudbursts in the thin Andean air.

We were the only souls for miles around.

Slowly thestars dimmed and the moon plunged.

What followed was an operatic daybreak.

explora.com; seven-night private itineraries on the Travesia Atacama-Uyuni route from $8,400 per person, all-inclusive.